<i>Giardia duodenalis</i>potentiates macrophage IL-10 production in response to LPS.

Abstract Giardia duodenalis is one of the world's most common intestinal parasites, with an estimated 280 million cases globally each year. Infections can cause diarrhea and cramps, although they are often subclinical. Interestingly, have a protective effect reduce incidence fatal in co-infections other enteric pathogens. In this study, we investigate anti-inflammatory response to via macrophage galactose lectin-type 1 (MGL1) receptor. Our reasons for choosing receptor three-fold: it expressed on macrophages some dendritic cells plays role immune pathogens, has been shown induce effects DSS colitis model, demonstrably binds galactose-containing carbohydrates, like N-Acetylgalactosamine (GalNAc) present cell wall cysts. We show that peritoneal isolated from wildtype C57BL/6 mice produce markedly more cytokine IL-10 when stimulated lipopolysaccharide (LPS) extract compared LPS alone. The potentiated lost MGL1 knockout or extracts centrifuged at 10,000 X g. Elucidating pathway not only promises better understanding giardiasis, which disproportionately affect lower-middle income communities. also might opportunities mimic parasite treatment wide array inflammatory diseases. Supported by grant NIH (R15 AI109591).